| Thousands of patients have been treated there but, by next year, the wards in Princess Royal Hospital will be empty.
Hull and East Yorkshire Hospitals NHS Trust is moving services from the east Hull site to a new £70m cancer centre at Castle Hill Hospital in Cottingham.
The closure of Princess Royal Hospital moved a step closer after Hull City Council's health overview and scrutiny committee agreed the trust did not need to consult the public on the disposal of the site.
Trust chief executive Stephen Greep explained there had already been several consultations about moving services from the Saltshouse Road hospital to Cottingham.
He said: "There have been public consultations in 1999, 2001 and last year about Princess Royal Hospital services being moved and future community provision.
"But there was never formal public consultation on closing the site, although by next year there will be no services on it."
In 2005, city pensioners signed a petition to try to save the hospital.
They said they had not been properly consulted by the then East Riding and Hull Health Authority, which carried out a consultation in 2001.
The consultation was about the new cancer centre at Castle Hill but some said it was not clear at that time the new centre would result in the closure of Princess Royal Hospital.
It is not yet known what will happen to the site, but it is thought Hull Teaching Primary Care Trust, which runs community health services in the city such as GP surgeries and dentists, does not want it, as the organisation is expanding services elsewhere in the east of the city.
Services have gradually moved from Princess Royal Hospital in recent years, but some cancer patients are still treated there.
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